EFFECT OF MODERATE SWIMMING EXERCISE WITH A DIETARY VITAMIN D ON SERUM IRISIN LEVEL IN DIABETIC RATS

Background: Irisin is a recent myokine that decreases obesity and enhances insulin resistance by converting white adipose tissues to brown, leading increase thermogenesis lower resistance. Objective: The impact of moderate swimming exercise combined with dietary vitamin D on serum irisin levels was evaluated in type II diabetes rat model (T2DM). Material Methods: This study conducted between September December 2020 50 male adult albino rats at the animal house physiology department, Al-Azhar university. Rats have been split into 5 equal groups: Group I control group, diabetic III IV group received D, V D. Serum collected after experiment determine glucose, insulin, levels, lipid profiles. Results: Diabetic exhibited hyperglycemia, hyperlipidemia, high accompanied significant hypoinsulinemia, low level. results also showed supplementation improved level irisin, resistance, profile (Cholesterol, LDL, triglycerides) rats. combination gives best effects. Conclusion: Vitamin very beneficial patients. can be used later as biomarker for it had strong negative association it.